The MACS® MiniSampler, attached to the autoMACS™ Pro separator, can hold one of three different MACS® Cooling Tube Racks containing up to six samples. Cell separation is programmed using the touch screen and intuitive menus. Before starting the process, the instrument automatically checks the status of the autoMACS® columns, as well as the fluids required for separation and system rinsing.

After starting the cell separation program (positive separation, depletion, etc.), the instrument takes the sample for magnetic separation. Depending on the separation program, magnetic separation is carried out automatically on one or two columns. Unlabeled and labeled fractions are eluted in two different tubes, and both can be used for a wide variety of downstream applications. The instrument then automatically moves on to the next sample. Between cell separations, the fluid system is automatically cleaned.