Liste de nos publications

Rappel : conformément à notre règlement intérieur, tout travail ayant fait appel à nos services implique une citation de la plateforme Imaflow dans le matériel et méthodes.

Comment nous citer : Flow Cytometry/Microscopy experiments were performed at the ImaFlow core facility (Biologie Santé Dijon BioSanD US58, 21079, Dijon, France) supported by Burgundy Regional Council.


Benoit-Lizon I, Jacquin E, Rivera Vargas T, Richard C, Roussey A, Dal Zuffo L, Martin T, Mélis A, Vinokurova D, Shahoei SH, Baeza Garcia A, Pignol C, Giorgiutti S, Carapito R, Boidot R, Végran F, Flavell R, Ryffel B, Nelson ER, Soulas-Sprauel P, Lawrence T, Apetoh L (2022) CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells. J Immunother Cancer, in press.

Gérard Claire, Thébault Marine, Lamarthée Baptiste, Genet Coraline, Cattin Florine, Brazdova Andréa, Janikashvili Nona, Cladière Claudie, Ciudad Marion, Ouandji Séthi, Ghesquière Thibault, Greigert Hélène, Tinel Claire, Adotevi Olivier, Saas Philippe, Samson Maxime, Audia Sylvain, Bonnotte Bernard (2022) Human Monocyte-Derived Suppressor Cell Supernatant Induces Immunoregulatory Effects and Mitigates xenoGvHD. Frontiers in Immunology     VOLUME=13     

Blot M,  Jacquier M,  Pauchard L-A,  Rebaud C,  Marlin C,  Hamelle C, Bataille A,  Croisier D,  Thomas C,   Jalil A,  Mirfendereski H, Piroth L, Chavanet P, Bensoussan D, Laroye C,  Reppel L, Charles P-E (2022). Adverse Mechanical Ventilation and Pneumococcal Pneumonia Induce Immune and Mitochondrial Dysfunctions Mitigated by Mesenchymal Stem Cells in Rabbits. Anesthesiology  Vol. 136, 293–313.

Emeric Limagne, Lisa Nuttin, Marion Thibaudin, Elise Jacquin, Romain Aucagne, Marjorie Bon, Solene Revy, Robby Barnestein, Elise Ballot, Caroline Truntzer, Valentin Derangere, Jean-David Fumet, Charlene Latour, Cedric Rebe, Pierre-Simon Bellaye, Coureche-Guillaume Kaderbhaı, Aodrenn Spill, Bertrand Collin, Mary B. Callanan, Aurelie Lagrange, Laure Favier, Bruno Coudert, Laurent Arnould, Sylvain Ladoire, Bertrand Routy,10 Philippe Joubert,and Francois Ghiringhelli (2022) MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells. Cancer Cell 40, 136–152.e1–e12

Lebrun, L.J.; Pallot, G.; Nguyen, M.; Tavernier, A.; Dusuel, A.; Pilot, T.; Deckert, V.; Dugail, I.; Le Guern, N.; Pais De Barros, J.-P.; Benkhaled, A.; Choubley, H.; Lagrost, L.; Masson, D.; Gautier, T.; Grober, J. (2022) Increased Weight Gain and Insulin Resistance in HF-Fed PLTP Deficient Mice Is Related to Altered Inflammatory Response and Plasma Transport of Gut-Derived LPS. Int. J. Mol. Sci. 2022, 23, 13226.

Bruchard, M, Geindreau, M, Perrichet, A, Truntzer, C, Ballot, E, Boidot, R, Racoeur, C, Barsac, E, Chalmin, F, Hibos, C, Baranek, T, Paget, C, Ryffel, B, Rébé, C, Paul, C, Végran, F & Ghiringhelli, F (2022) Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses. Nature Immunology, vol. 23, no. 2, pp. 262–274.

Kieu, T.-L.-V., Pierre, L., Derangère, V., Perrey, S., Truntzer, C., Jalil, A., Causse, S., Groetz, E., Dumont, A., Guyard, L., Arnould, L., de Barros, J.-P. P., Apetoh, L., Rébé, C., Limagne, E., Jourdan, T., Demizieux, L., Masson, D., Thomas, C., … Rialland, M. (2022). Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors. Cell Death & Disease, 13(9), 758.

Mary R, Chalmin F, Accogli T, Bruchard M, Hibos C, Melin J, Truntzer C, Limagne E, Derangère V, Thibaudin M, Humblin E, Boidot R, Chevrier S, Arnould L, Richard C, Klopfenstein Q, Bernard A, Urade Y, Harker JA, Apetoh L, Ghiringhelli F, Végran F.(2022) Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects. Cancer Immunol Res. 2022 Jul 1;10(7):900-916.

Ghione S, Racoeur , Mabrouk N, Shan J, Groetz E, Ballot E, Truntzer C, Chouchane L, Végran F, Paul C, Plenchette S, Bettaieb A (2022) Protein Kinase Inhibitor-Mediated Immunoprophylactic and Immunotherapeutic Control of Colon Cancer. Frontiers in Immunology ; Volume 13.  

B. Rousselle, A. Massot, M. Privat, L. Dondaine, A. Trommenschlager, F. Bouyer, J. Bayardon, F. Ghiringhelli, A. Bettaieb, C. Goze, C. Paul, R. Malacea-Kabbara, E. Bodio,  (2022) Conception and Evaluation of Fluorescent Phosphine-Gold Complexes: From Synthesis to in vivo InvestigationsChem Med Chem 17, e202100773.

Wendremaire, M., Lopez, T. E., Barrichon, M., Zhang, H., Hadi, T., Ye, X.-Y., Neiers, F., Bardou, M., Sagot, P., Garrido, C., & Lirussi, F. (2022). Leptin-Induced HLA-G Inhibits Myometrial Contraction and Differentiation. Cells (2073-4409), 11(6), 954.

Georgievski, A., Michel, A., Thomas, C., Mlamla, Z., Pais de Barros, J.-P., Lemaire-Ewing, S., Garrido, C., & Quéré, R. (2022). Acute lymphoblastic leukemia-derived extracellular vesicles affect quiescence of hematopoietic stem and progenitor cells. Cell Death & Disease, 13(4), 337.

Denimal D, Benanaya S, Monier S, Simoneau I, Pais de Barros JP, Le Goff W, Bouillet B, Vergès B, Duvillard L. (2022) Normal HDL Cholesterol Efflux and Anti-Inflammatory Capacities in Type 2 Diabetes Despite Lipidomic Abnormalities. J Clin Endocrinol Metab 18;107(9):e3816-e3823.

Elmallah M. I. Y., Ortega-Deballon P., Hermite L., Pais-De-Barros J.P, Gobbo J. and Garrido C. (2022) Lipidomic profiling of exosomes from colorectal cancer cells and patients reveals potential biomarkers. Molecular Oncology 16 (2022) 2710–2718


Bernard A, Hibos C, Richard C, Viltard E, Chevrier S, Lemoine S, Melin J, Humblin E, Accogli T, Chalmin F, Bruchard M, Peixoto P, Hervouet E, Apetoh L, Ghiringhelli F, Vegran F and Boidot R (2021) The Tumor Microenvironment Impairs Th1 IFNg Secretion through Alternative Splicing Modifications of Irf1 Pre-mRNA. Cancer Immunol Res; 9(3) March 2021.

Niogret J, Berger H, Rebe C, Mary R, Ballot E, Truntzer C, Thibaudin M, Derangère V, Hibos C, Hampe L, Rageot D, Accogli T, Joubert P, Routy B, Harker J, Vegran F, Ghiringhelli F, Chalmin F (2021) Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy. J Immunother Cancer 2021;9:e002157.

Lahmar A, Mathey A, Aires V, Elgueder D , Vejux A , Khlifi R, Sioud F, Chekir-Ghedira L  and Delmas D (2021) Essential Oils, Pituranthos chloranthus and Teucrium ramosissimum, Chemosensitize Resistant Human Uterine Sarcoma MES-SA/Dx5 Cells to Doxorubicin by Inducing Apoptosis and Targeting P-Glycoprotein. Nutrients 2021, 13, 1719.

Privat M, Bellaye P-S, Lescure R, Massot A, Baffroy O, Moreau M, Racoeur C, Marcion G, Denat F, Bettaieb A, Collin B, Bodio E, Paul C, Goze C (2021) Development of an Easily Bioconjugatable Water-Soluble Single-Photon Emission-Computed Tomography/Optical Imaging Bimodal Imaging Probe Based on the aza-BODIPY Fluorophore. Journal of Medicinal Chemistry Volume 64, Issue 15, 12 , Pages 11063-11073

Bouaouiche, S.; Ghione, S.; Sghaier, R.; Burgy, O.; Racoeur, C.; Derangère, V.; Bettaieb, A.; Plenchette, S. (2021) Nitric Oxide-Releasing Drug Glyceryl Trinitrate Targets JAK2/STAT3 Signaling, Migration and Invasion of Triple-Negative Breast Cancer Cells. Int. J. Mol. Sci. 2021, 22, 8449.

Uyanik B, Goloudina AR, Akbarali A, Grigorash BB, Petukhov AV,  Singhal S, Eruslanov E, Chaloyard J, Lagorgette L, Haldi Y, Baidyuk E.V, Sakai H, Tessarollo L, Ryffel B, Mazur S-J, Lirussi F, Garrido C, Appella E, Demidov O-N. (2021). Inhibition of the DNA Damage Response Phosphatase PPM1D Reprograms Neutrophils to Enhance Anti-Tumor Immune Responses. NATURE COMMUNICATIONS, 12:3622,

Marcion G, Hermetet F, Neirs F, Uyanik B, Dondaine L, Dia AMM, Da Costa L, Moreau M, Bellaye PS, Collin B, Kitten O, Briand L, Cinier M, Garrido C. Nanofitins targeting heat shock protein 110: an innovative strategy in colon cancer immunotherapy. Int J Cancer 1–13.

Dias AMM, Douhard R, Hermetet F, Regimbeau M, Lopez T, Gonzalez D, Masson S, Marcion G, Chaumonnot K, Uyanik B, , Causse SZ, Rieu A, Hadi T, Basset C, Chluba J, Grober J, Guzzo G, Neiers F, Ortega-Deballon P, Demidov O, Lirussi F, Garrido C. (2021) Lactobacillus stress protein GroEL prevents colonic inflammation. Journal of Gastroenterology. J Gastroenterol (2021) 56:442–455.

Chaumonnot K, Masson S, Sikner H, Bouchard A, Baverel V, Bellaye P-S, Collin B, Garrido C and Kohli E. The HSP GRP94 interacts with macrophage intracellular complement C3 and impacts M2 profile during ER stress. Cell Death & Dis 12:114.

Mshaik R, Simonet J , Georgievski A , Jamal L , Bechoua S , Ballerini P, Bellaye P-S, Mlamla Z, Pais de Barros J-P, Geissler A , Francin P-J, Girodon F, Garrido C and Quéré R (2021) HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias. Blood Cancer Journal 11:61.

Belkahla H, Constantinescu AA, Gharbi T, Barbault F, Chevillot-Biraud A, Decorse P, Micheau O, Hémadi M, Ammar S. (2021) Grafting TRAIL through Either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency. Nanomaterials (Basel). 17;11(2):502. doi: 10.3390/nano11020502.PMID: 33671136.

Abdelkafi-Koubaa Z, ELBini-Dhouib I, Souid S, Jebali J, Doghri R, Srairi-Abid N, Essafi-Benkhadir K, Micheau O, Marrakchi N (2021). Pharmacological Investigation of CC-LAAO, an L-Amino Acid Oxidase from Cerastes cerastes Snake Venom. Toxins (Basel). 16;13(12):904. doi: 10.3390/toxins13120904.PMID: 34941741.

Louise Ménégaut, Antoine Jalil, Thomas Pilot, Kevin van Dongen, Valentin Crespy, Eric Steinmetz, Jean Paul Pais de Barros, Audrey Geissler, Wilfried Le Goff, Nicolas Venteclef, Laurent Lagrost, Thomas Gautier, Charles Thomas, David Masson (2021) Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for Liver X receptors Oxysterols modulate glycolysis in human macrophages. British Journal of Pharmacology Vol178, Issue 16.

Aloïs Dusuel, Valérie Deckert, Jean-Paul País de Barros, Kevin van Dongen, Hélène Choubley, Émilie Charron, Naig Le Guern, Jérôme Labbé, Stéphane Mandard,, Jacques Grober, Laurent Lagrost, Thomas Gautier (2021) Human cholesteryl ester transfer protein lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice. Journal of Lipid Research 62 100011.

Bourgeois T, Jalil A, Thomas C, Magnani C, Le Guern N, TGautier T, Pais de Barros J-P, Bergas V, Choubley H, Mazzeo L, Menegaut L, Lebrun L, Van Dongen K, Xolin M, Jourdan T, Buch C, Labbé J, Saas P, Lagrost L, Masson D, Grober J (2021). Deletion of lysophosphatidylcholine acyltransferase3 in myeloid cells worsens hepatic steatosis after a high fat diet. Journal of Lipid Research. J. Lipid Res. (2021) 62 100013.

Blot M, David Masson, Nguyen M, Bourredjem A; LYMPHONIE Study Group; Binquet C, Piroth L. (2021) Are adipokines the missing link between obesity, immune response, and outcomes in severe COVID-19? Int J Obes (Lond). 2021 Sep;45(9):2126-2131. 31

Maxime Samson, Helene Greigert, Marion Ciudad, Claire Gerard, Thibault Ghesquiere, Malika Trad, Marc Corbera-Bellalta, Coraline Genet, Sethi Ouandji, Claudie Cladiere, Marine Thebault, Kim Heang Ly, Eric Liozon, Francois Maurier, Boris Bienvenu, Benjamin Terrier, Lo€ıc Guillevin, Pierre Charles, Valerie Quipourt, Herve Devilliers, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Georges Tarris, Laurent Martin, Philippe Saas, Sylvain Audia, Maria Cinta Cid & Bernard Bonnotte  (2021) Improvement of Treg immune response after treatment with tocilizumab in giant cell arteritis. Clinical & Translational Immunology 2021; e1332

Nona Janikashvili, Claire Gérard, Marine Thébault, Andrea Brazdova, Clovis Boibessot, Claudie Cladière, Marion Ciudad, Hélène Greigert, Séthi Ouandji, Thibault Ghesquière, Maxime Samson, Sylvain Audia, Philippe Saas & Bernard Bonnotte (2021) Efficiency of human monocyte-derived suppressor cell-based treatment in graft-versus-host disease prevention while preserving graft-versus-leukemia effect, OncoImmunology, 10:1, 1880046

Ghesquière, T, Ciudad, M, Ramon, A, Greigert, H, Gerard, C, Cladière, C, Thébault, M, Genet, C, Devilliers, H, Maurier, F, Ornetti, P, Quipourt, V, Gabrielle, P-H, Creuzot-Garcher, C, Tarris, G, Martin, L, Soudry-Faure, A, Saas, P, Audia, S, Bonnotte, B & Samson, M (2021) Mucosal-associated invariant T cells in Giant Cell Arteritis, Journal of Autoimmunity, vol. 121


Chevriaux, A., Pilot, T., Derangère, V., Simonin, H., Martine, P., Chalmin, F., Ghiringhelli, F., Rébé, C. (2020). Cathepsin B is required for NLRP3 inflammasome activation in macrophages, through NLRP3 interaction. Front. Cell Dev. Biol. Volume 8 | Article 167

Sioud, F., Amor, S., Toumia, I. ben, Lahmar, A., Aires, V., Chekir-Ghedira, L., Delmas, D. (2020). A New Highlight of Ephedra alata Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo. Cells (2073-4409), 9(2), 362.

Gozzi G, Gonzalez D, Boudesco C, Dias A, Gotthard G, Uyanik B, Dondaine L, Marcion G, Suzanne P, Douhard R, Dubrez L, Demidov O, Neiers F, Briand L, Voisin-Chiret AS, Garrido C. (2020). Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy. Cell Death & Differentiation 27:117–129

Marine Cordonnier, Charlée Nardin, Gaëtan Chanteloup, Valentin Derangere,  Marie-Paule Algros, Laurent Arnould, Carmen Garrido, François Aubinc, Jessica Gobbo (2020) Tracking the evolution of circulating exosomal-PD-L1 to monitor melanoma patients. Journal of extracellular vesicles, vol. 9, 1710899


Martine, P., Chevriaux, A., Derangère, V., Apetoh, L., Garrido, C., Ghiringhelli, F., Rébé, C. (2019). HSP70 is a negative regulator of NLRP3 inflammasome activation. Cell Death & Disease, 10(4), 256.

Adélie Dumont, Charlotte de Rosny, Trinh-Le-Vi Kieu, Sabrina Perrey , Hélène Berger, Aurélie Fluckiger, Tania Muller, Jean-Paul Pais de Barros, Laurent Pichon , Aziz Hichami, Charles Thomas, Cédric Rébé, François Ghiringhelli, Mickaël Rialland (2019). Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNKmediated mature IL-1β secretion in 5- fluorouracil-treated MDSC: implication in cancer treatment. Cell Death & Disease 10:485

Lucie Demontoux, Valentin Derangère, Thomas Pilot, Chloé Thinselin, Angélique Chevriaux, Fanny Chalmin, Florence Bouyer, François Ghiringhelli, Cédric Rébé (2019). Hypotonic stress enhances colon cancer cell death induced byplatinum derivatives and immunologically improves antitumorefficacy of intraperitoneal chemotherapy. International Journal of Cancer  145, 3101–3111

Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C, Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E, Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S, Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V, Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G. (2019). Crizotinib-induced immunogenic cell death in  non-small cell lung cancer. Nature Communication 2;10(1):1486.

Anne Buffière, Benjamin Uzan, Romain Aucagne, François Hermetet, Manon Mas, Sandra Nassurdine, Aziza Aznague, Virginie Carmignac, Benjamin Tournier, Olivier Bouchot, Paola Ballerini, João T. Barata, Jean-Noël Bastie, Laurent Delva, Françoise Pflumio, Ronan Quéré (2019). T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7. Oncogene 38, pages7357–7365

François Hermetet, Anne Buffière, Aziza Aznague, Jean-Paul Pais de Barros, Jean-Noël Bastie, Laurent Delva,  Ronan Quéré. (2019). High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow. Nature Communications  10, Article number: 523 

Carmignac, V., Barberet, J., Iranzo, J., Quéré, R., Guilleman, M., Bourc’his, D., & Fauque, P. (2019). Effects of assisted reproductive technologies on transposon regulation in the mouse pre-implanted embryo. Human Reproduction, 34(4), 612–622.

Bouaouiche S, Magadoux L, Dondaine L, Reveneau S, Isambert N, Bettaieb A, Jeannin JF, Laurens V, Plenchette S. (2019) Glyceryl trinitrate induced cytotoxicity of docetaxel resistant prostatic cancer cells is associated with differential regulation of clusterin. International Journal of Oncology. 54: 1446-1456

Duplomb, L., Rivière, J., Jego, G., Da Costa, R., Hammann, A., Racine, J., Schmitt, A., Droin, N., Capron, C., Gougerot-Pocidalo, M.-A., Dubrez, L., Aral, B., Lafon, A., Edery, P., Ghoumid, J., Blair, E., El Chehadeh-Djebbar, S., Carmignac, V., Thevenon, J., … Solary, E. (2019). Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia. Journal of Molecular Medicine, 97(5), 633

Causse S, Marcion G, Chanteloup G, Uyanik B, Boudesco C, Douhard R, Dias AMM, Dondaine L, Moussay E, Paggetti J, de Thonel A, Duvrez L, Demidov O, Gobbo J, Garrido C. (2019). HSP110 trasnlocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells. Oncogene 38:2767-2777, 2019

Dubuisson, A., Favreau, C., Fourmaux, E., Lareure, S., Rodrigues-Saraiva, R., Pellat-Deceunynck, C., El Alaoui, S., Micheau, O. (2019). Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization. Cell Death & Disease, 10(2).

Sali Wahib, Patoli Danish, Pais de Barros Jean-Paul, Labbé Jérôme, Deckert Valérie, Duhéron Vincent, Le Guern Naig, Blache Denis, Chaumont Denis, Lesniewska Eric, Gasquet Benoit, Paul Catherine, Moreau Mathieu, Denat Franck, Masson David, Lagrost Laurent, Gautier Thomas (2019). Polysaccharide Chain Length of Lipopolysaccharides From Salmonella Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity in vivo . Frontiers in Microbiology  Vol 10 pp1774